Discovery of test reagents, diagnostic agents, and therapeutic agents using physicochemical properties of carborane cage

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790115
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: Tohoku Pharmaceutical University
• Principal Investigator: OHTA Kiminori 東北薬科大学, 薬学部, 講師 (90347906)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ホウ素クラスター / 創薬化学 / 分子認識 / 超分子化学

Outline of Final Research Achievements

Based on the physicochemical properties of carboranes, bio-functional molecules, which recognize biogenic substances, were designed and synthesized. Several discovered anion receptors for fluoride and chloride are useful as reagents for detection of their anions in the environment as well as treatment for the diseases related with their anions. In addition, several anion receptors showed cancer cell proliferation inhibitory activity. SAR studies suggested that carborane cage is essential for anti-cancer activity.
These results are important milestones in the application of molecular recognition with carborane cage to test reagents, diagnostic agents, and therapeutic agents.

Free Research Field

創薬化学