2013 Fiscal Year Final Research Report
Basic medicinal chemistry based on behavioral structure-building regulation of protein
| Project/Area Number |
24790119
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 虚血／再灌流障害 / HCV / フォールディング / ダントロレン |
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| Research Abstract |
In this study, we tried to establish innovative drug development methodology by using a basic medicinal chemistry based on behavioral structure-building regulation of protein. A target of this study is folding regulatory factor, and illness to intend for both ischemia/reperfusion induced cell death and hepatitis C virus reproduction. As a result, we succeeded in development of compounds which have inhibitory effect of Ca2+-induced mitochondrial swelling. These compounds were considered to be capable of inhibitor for the ischemia/reperfusion induced cell death.
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