2014 Fiscal Year Final Research Report
Antimicrobial effect of allograft and development of its preservation
| Project/Area Number |
24790129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | Ａｌｌｏｇｒａｆｔ / 感染性心内膜炎 / 抗菌薬カクテル |
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| Outline of Final Research Achievements |
In this study, I demonstrated that the mechanism of antimicrobial activity in allograft, which has been used in surgical therapy for the patients with infectious endocarditis, is the tryptophan metabolites. Additionally, I demonstrated that the cryopreserved allograft has the same or more antimicrobial activity than the fresh allograft. Furthermore, development of the brand new antimicrobial cocktail, which was able to prevent the bacterial contamination of allograft more effective than traditional one, was carried out in vitro experiment successfully.
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| Free Research Field |
病原微生物学
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