2013 Fiscal Year Final Research Report
Regulation of the immune response by nuclear receptor PXR
| Project/Area Number |
24790142
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
KODAMA SUSUMU 東北大学, 薬学研究科(研究院), 助教 (20621460)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 核内受容体 / 異物応答 / 免疫系 / 細胞シグナル |
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| Research Abstract |
We investigated the anti-inflammatory activity of PXR in a mouse model of immune-mediated liver injury induced by concanavalin A (Con A). In this model, PXR knockout mice displayed augmented liver damage compared with wild-type mice. Pretreatment of wild-type mice with PCN, a potent mouse PXR activator, prior to Con A challenge led to an amelioration of liver injury, which was accompanied by reduction of Con A-induced chemokine mRNA expression and neutrophil infiltration. These data suggest that PXR protects liver from Con A-induced injury by repressing the hepatic immune response.
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