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2013 Fiscal Year Final Research Report

Regulation of the immune response by nuclear receptor PXR

Research Project

  • PDF
Project/Area Number 24790142
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionTohoku University

Principal Investigator

KODAMA SUSUMU  東北大学, 薬学研究科(研究院), 助教 (20621460)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords核内受容体 / 異物応答 / 免疫系 / 細胞シグナル
Research Abstract

We investigated the anti-inflammatory activity of PXR in a mouse model of immune-mediated liver injury induced by concanavalin A (Con A). In this model, PXR knockout mice displayed augmented liver damage compared with wild-type mice. Pretreatment of wild-type mice with PCN, a potent mouse PXR activator, prior to Con A challenge led to an amelioration of liver injury, which was accompanied by reduction of Con A-induced chemokine mRNA expression and neutrophil infiltration. These data suggest that PXR protects liver from Con A-induced injury by repressing the hepatic immune response.

  • Research Products

    (5 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics2013

    • Author(s)
      Kodama S and Negishi M. Sulfotransferase genes
    • Journal Title

      Drug Metabolism Reviews

      Volume: 45 Pages: 441-449

    • DOI

      10.3109/03602532.2013.835630

    • Peer Reviewed
  • [Journal Article] PXR cross-talks with internal and external signals in physiological and pathophysiological responses2013

    • Author(s)
      Kodama S and Negishi M
    • Journal Title

      Drug Metabolism Reviews

      Volume: 45 Pages: 300-310

    • DOI

      10.3109/03602532.2013.795585

    • Peer Reviewed
  • [Presentation] 核内受容体PXRによる免疫反応調節の機序解明2013

    • Author(s)
      志村匠斗、児玉進、栗林秀明、宮田昌明、山添康、吉成浩一
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-10-20
  • [Presentation] 核内受容体PXRによる免疫反応調節の機序解明2013

    • Author(s)
      志村匠斗、児玉進、栗林秀明、宮田昌明、山添康、吉成浩一
    • Organizer
      第40回日本毒性学会学術年会
    • Place of Presentation
      千葉
    • Year and Date
      2013-06-17
  • [Presentation] 核内受容体PXRはコンカナバリンA投与により誘導されるT細胞依存性肝炎を抑制する2012

    • Author(s)
      児玉進、志村匠斗、栗林秀明、吉成浩一、山添康
    • Organizer
      日本薬物動態学会第27回年会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-22

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Published: 2015-06-25  

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