2013 Fiscal Year Final Research Report
Biomarker discovery for chemotherapy-induced peripheral neuropathy
| Project/Area Number |
24790143
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI NAOTO 東北大学, 薬学研究科(研究院), 准教授 (60372299)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 末梢神経障害 / バイオマーカー |
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| Research Abstract |
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe dose-limiting side effect of anticancer drugs because of the lack of effective care. The aim of this study was to discover the biomarkers for early diagnosis and optimal care of CIPN using NGF-differentiated PC12D cells. After treatment with anticancer drugs such as oxaliplatin, paclitaxel and bortezomib, intracellular metabolites were extracted and analyzed by liquid chromatography/mass spectrometry (LC/MS). LC/MS analysis revealed some characteristic changes in the concentration of intracellular metabolites related to treatment with specific types of anticancer drugs.
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