2013 Fiscal Year Final Research Report
Neural activity-dependent attenuation of PGE2 elimination across the blood-brain barrier and molecular mechanisms of this attenuation
| Project/Area Number |
24790148
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
AKANUMA Shin-ichi 富山大学, 大学院医学薬学研究部(薬学), 助教 (30467089)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | PGE2 / 血液脳関門 / グルタミン酸 / プロスタグランジン / 神経伝達物質 / 有機アニオン輸送担体 / クリアランス / グルタミン酸受容体 |
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| Research Abstract |
L-Glutamate is reported to be involved in the excitatory neural responses. Using rat brain efflux index method, I evaluated the effect of intracerebral L-glutamate on prostaglandin E2 (PGE2) elimination across the blood-brain barrier (BBB). By the pre-administration of L-glutamate, the elimination of PGE2 across the BBB was attenuated. This attenuation of PGE2 elimination was abolished by the co-existence of antagonists for N-methyl-D-aspartate (NMDA)-type L-glutamate receptors. In addition, the elimination of PGE2 across the BBB was attenuated by the pre-administration of agonists for NMDA-type L-glutamate receptors as well as L-glutamate. These results suggest that L-glutamate attenuates PGE2 elimination across the BBB via NMDA-type L-glutamate receptor-mediated processes.
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