The mechanism of anti-HIV drug-related dyslipidemia in patients with HIV infection

2015 Fiscal Year Final Research Report

• Project/Area Number: 24790153
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Osaka University
• Principal Investigator: Tsugane Mamiko 大阪大学, 薬学研究科(研究院), 招へい教員 (00469991)
• Project Period (FY): 2013-02-01 – 2016-03-31
• Keywords: 抗HIV薬 / 脂質代謝異常 / 11β-HSD1 / 臨床薬学

Outline of Final Research Achievements

The principal aim of the present study was to determine the mechanism of dyslipidemia, which occurs during the long-term use of anti-HIV drugs. We investigated patient background information based on medical records, clinical test values, and drug use in HIV-infected patients, and evaluated the activity of the glucocorticoid-activating enzyme, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in urine samples using liquid chromatography/mass spectrometry. Our results revealed high activity of 11β-HSD1 according to the urine metabolite data in patients who used antidyslipidemic drugs combined with anti-HIV drugs and in patients with increased blood low-density lipoprotein levels after the use of anti-HIV drugs. These results suggest that 11β-HSD1 is involved in anti-HIV drug-related dyslipidemia.

Free Research Field

臨床薬学