2014 Fiscal Year Final Research Report
Redox analysis of antihyperuricemic agent and application to CKD/CVD treatment
| Project/Area Number |
24790160
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 高尿酸血症 / ベンズブロマロン / 酸化ストレス |
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| Outline of Final Research Achievements |
Hyperuricemia, begins with induction of oxidative stress which closely related to the renin angiotensin system, is related to the onset and the progression of cardiovascular disease (CVD) and chronic kidney disease (CKD). Therefore, reduction of oxidative stress is important in hyperuricemia. In the present study, we evaluate the antioxidant effects of uricosuric agent benzbromarone. As a result, Benzbromarone has a direct radical scavenging activity against superoxide radicals and reduced oxidative stress induced by angiotensin II in the endothelial cell. Furthermore, benzbromarone exerts a direct antioxidant action in angiotensin II and salt induced-hypertension model rats. These results revealed that benzbromarone exerts a direct antioxidant action in the body. It is expected in the future that benzbromarone may be useful agent as a multiple antioxidants for the prevention of CVD and CKD.
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| Free Research Field |
医療薬学
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