2014 Fiscal Year Final Research Report
Development of novel nanocarrier for follicular delivery
| Project/Area Number |
24790163
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
|
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | ベシクル / 毛包デリバリー |
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| Outline of Final Research Achievements |
In current study, sucrose laurate based vesicles were prepared. Drug loading into the vesicle resulted in the enhancement of drug skin permeation. By the application of coumarin-6 loaded in the vesicle on the skin, accumulation of coumarin-6 was observed into hair follicles. Our vesicle formulations are prepared using additives which is including the Japanese Pharmaceutical Excipients or Japanese Cosmetic Ingredients Codex. Therefore, it might be effective nanocarrier of transdermal delivery for the clinical application as hospital preparation. However, more investigation will be needed including formulation change for highly transitivity into the hair follicles and skin irritation test of vesicle formulations. It would be strongly expected for further development of this research.
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| Free Research Field |
医療薬学
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