2013 Fiscal Year Final Research Report
Evaluation of circulating miRNA in exosomes for novel biomarker of arteriosclerosis
| Project/Area Number |
24790164
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
IWAKI Soichiro 名古屋市立大学, 薬学研究科(研究院), 講師 (60399962)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | miRNA / バイオマーカー / 動脈硬化症 |
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| Research Abstract |
To identify the novel miRNA markers for arteriosclerosis, we first screened total RNA samples derived from patient's plasma using a microarray platform. As a result, several circulating miRNAs were identified to be differentially expressed. We also demonstrated that optimal RNA extraction method of miRNA from human plasma samples for quantitative PCR. These results suggest that circulating miRNAs are available as a novel biomarker to assess the arteriosclerosis.
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[Journal Article] TNF-αproduction in NKT cell hybridoma is regulated by sphingosine-1-phosphate : Ramifications of correlation between plasma S1P levels and metabolic syndrome2014
Author(s)
Shiori Ito, Soichiro Iwaki, Rie Kondo, Masashi Sato, Kazuya Iwabuchi, Ryunosuke Ohkawa, Yuko Mishima, Yutaka Yatomi, Tomoo Furumoto, Hiroyuki Tsutsui, Satoshi Fujii
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Journal Title
Coron Artery Dis
Volume: 25
Pages: 311-320
DOI
Peer Reviewed
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[Journal Article] Increased Plasma Sphingosine-1-Phosphate in Obese Subjects and Its Capacity to Increase Expression of Plasminogen Activator Inhibitor-1 in Adipocytes2013
Author(s)
Shiori Ito, Soichiro Iwaki, Keiko Koike, Yuichiro Yuda, Ayako Nagasaki, Ryunosuke Ohkawa, Yutaka Yatomi, Tomoo Furumoto, Hiroyuki Tsutsui, Burton E Sobel, Satoshi Fujii
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Journal Title
Coron. Artery Dis
Volume: 24
Pages: 642-650
DOI
Peer Reviewed
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[Journal Article] Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB2013
Author(s)
Naoki Mizutani, Misa Kobayashi, Sayaka Sobue, Masatoshi Ichihara, Hiromi Ito, Kouji Tanaka, Soichiro Iwaki, Satoshi Fujii, Yurie Ito, Keiko Tamiya-Koizumi, Akira Takagi, Tetsuhito Kojima, Tomoki Naoe, Motoshi Suzuki, Mitsuhiro Nakamura, Yoshiko Banno, Yoshinori Nozawa, Takashi Murate
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Journal Title
Biochim Biophys Acta
Volume: 1833
Pages: 1006-1016
DOI
Peer Reviewed
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