2013 Fiscal Year Final Research Report
Mechanism of hypotaurine transport by Slc6a13 for oxidative stress defense
| Project/Area Number |
24790171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
HIGUCHI Kei 帝京大学, 薬学部, 助教 (10625304)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ヒポタウリン / 酸化ストレス / Slc6a13 / 細胞保護効果 |
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| Research Abstract |
We clarified the protective effect of hypotaurine on TR-TBT18d-1 cells, rat placental cell line, exposed with oxidative stress. This study suggested that anti-hydroxyradical and -peroxyradical effects were involved in the protective effect of hypotaurine. Interestingly, the expression of rodent Slc6a13, which is a GABA transporter and express in peripheral organs such as placenta, was contributed to the protection against the oxidative stress and apoptosis induced by hydrogen peroxide.
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[Journal Article] System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts2014
Author(s)
Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Takahashi Y, Okazaki F, Sai Y, Higuchi K, Maruyama T, Tomi M, Nakashima E
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Journal Title
Biochim Biophys Acta
Volume: 1838(5)(Epub 2014 Jan 14)(PubMed PMID:24434061)
Pages: 1306-12
DOI
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