Research on the food-drug interaction focused on the nuclear receptor PPAR gamma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790182
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Kyushu University of Health and Welfare
• Principal Investigator: YOSHIDA Hiroki 九州保健福祉大学, 薬学部, 講師 (90469411)
• Research Collaborator: KUROKAWA Masahiko 九州保健福祉大学, 薬学部薬学科, 教授 (80186527) ; WATANABE Wataru 九州保健福祉大学, 薬学部薬学科, 教授 (50399218) ; SUGIRA Chihiro 九州保健福祉大学, 薬学部薬学科, 助教 (70632694) ; ATSUMI Toshiyuki 九州保健福祉大学, 薬学部薬学科, 助教 (60453651) ; NARUMI Keiko 九州保健福祉大学, 薬学部薬学科, 助教 (40551304)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 核内受容体 / PPARγ / 食品 / 医薬品 / 相互作用 / ナリンゲニン / ピオグリタゾン / 糖尿病

Outline of Final Research Achievements

We analyzed the interaction between ordinary food factors and anti-diabetic drug pioglitazone on the activation of PPAR gamma and the improvement of diabetes. Citrus flavonoid naringenin increased pioglitazone-induced PPAR gamma activation in vitro using a cell culture system. However, naringenin reduced the anti-diabetic effect of pioglitazone in vivo using a pathological mouse model. Naringenin did not affect serum pioglitazone concentration. In contrast, naringenin slightly affected the PPAR gamma-cofactors complex formation.

Free Research Field

生化学、医療薬科学