2014 Fiscal Year Final Research Report
Analysis of autophagy in myogenesis and skeletal muscle regeneration
| Project/Area Number |
24790190
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Gunma University |
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Principal Investigator |
UENO Hitoshi 群馬大学, 医学(系)研究科(研究院), 助教 (30586251)
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| Research Collaborator |
MORIMURA Yosihiro
MATSUDA Haruko
SUNOHARA Yukiko
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | オートファジー / 骨格筋形成 / 骨格筋再生 |
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| Outline of Final Research Achievements |
I analyzed the autophagy in the regeneration and the formation of the skeletal muscle. By the experiment of the regeneration, expression of LC3 increased after the damage of the skeletal muscle immediately and LC3 formed a small vesicle. Autophagosome was few in a myoblasts at the time of the skeletal muscle formation, but autophagosome was increased after differentiation, and autophagosome were become autolysosome when myoblasts differentiated into myotubes. These results suggested that the autophagy played an important role in the regeneration and the formation of the skeletal muscle.
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| Free Research Field |
骨格筋の細胞生物学
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