2013 Fiscal Year Final Research Report
Cell fate specification in gastrointestinal epithelial cells by helix-loop-helix factor Id2
| Project/Area Number |
24790194
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | University of Fukui |
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Principal Investigator |
MORI Kentaro 福井大学, 医学部, 助教 (50397296)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 細胞分化 / 消化管上皮 / 内胚葉 / 転写因子 / Id2 / Irx3 / Irx5 |
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| Research Abstract |
Gastrointestinal epithelial cells are derived from endoderm, and region-specific endoderm differentiation establishes the functionally distinct organ, esophagus, stomach and caudally positioned intestine. How region-specific epithelial characteristics are generated during development remains poorly understood. I have found that the knockout mice of transcriptional repressor Id2 develop intestinal tumors, and revealed that the tumors are derived from ectopic gastric tissues formed in the small intestine during development. This study demonstrates that Id2 is involved in the cell fate specification of the intestinal epithelial cells through the suppression of the foregut endoderm genes expression.
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