2013 Fiscal Year Final Research Report
Hepatoblasts might contribute to hepatic sinusoidal endothelial cells development
| Project/Area Number |
24790197
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kumamoto University |
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Principal Investigator |
NIKI Daisuke 熊本大学, 生命資源研究・支援センター, 厚労科研研究員 (10621914)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 肝芽細胞 / 肝類洞内皮細胞 / 肝臓発生 |
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| Research Abstract |
Hepatic sinusoidal endothelial cells are an important roles for hepatic development and regeneration, control of blood flow in liver and immunoreaction. However, developmental mechanism of hepatic sinusoidal endothelial cells is not a little known. Based on several literatures, we formulated a hypothesis which hepatoblasts might contribute hepatic sinusoidal endothelial cells development. In order to examine the hypothesis, we generated Hhex knockout mice as hepatoblasts-less liver mice. Hereafter, development of hepatic sinusoidal endothelial cells and roles of hepatoblasts are examined using Hhex knockout mice.
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