2013 Fiscal Year Final Research Report
Molecular mechanism and pathophysiology of nucleophagy induced by cation pump
| Project/Area Number |
24790209
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | University of Toyama |
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Principal Investigator |
FUJII Takuto 富山大学, 大学院医学薬学研究部(薬学), 助教 (50567980)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 生理学 / 細胞 / 細胞死 / P型ATPase / オートファジー / ヌクレオファジー |
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| Research Abstract |
In this research, the molecular mechanism and pathophysiology of nucleophagy induced by human ATP13A4 were examined. We found that human ATP13A4 had no ion-transporting function and its N-terminal region was essential for induction of nucleophagy. On the other hand, mouse ATP13A4 had cation-transporting function and did not induce nucleophagy. Related proteins for the ATP13A4-induced nucleophagy were identified by DNA microarray and proteomics. Especially, increased expression levels of proteins involved in proteolytic system and cellular stress response were observed in human ATP13A4-expressing cells.
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[Journal Article] Functional coupling of chloride-proton exchanger ClC-5 to gastric H^+,K^+-ATPase2014
Author(s)
Takahashi Y., Fujii T., Fujita K., Shimizu T., Higuchi T., Tabuchi Y., Sakamoto H.,Naito I., Manabe K., Uchida S., Sasaki S., Ikari A., Tsukada K., Sakai H
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Journal Title
Biol. Open.
Volume: Vol. 3
Pages: 12-21
DOI
Peer Reviewed
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