2013 Fiscal Year Final Research Report
Control of polyglutamine protein aggregation by eEF1BdeltaL
| Project/Area Number |
24790217
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Kumamoto University |
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Principal Investigator |
KAITSUKA Taku 熊本大学, 大学院生命科学研究部, 助教 (00435926)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 選択的スプライシング / ポリグルタミン病 / 行動解析 / 学習・記憶 |
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| Research Abstract |
In previous study, we have found that eEF1BdeltaL is a new brain-specific transcriptional factor involved in stress responses. In this study, to investigate the role of eEF1BdeltaL in the pathophysiology of polyglutamine diseases, several experiments were done. However, obvious evidence that eEF1BdeltaL influences on polyglutamine protein aggregation has not been obtained. Then the phenotype of eEF1BdeltaL knockout mice was examined. These mice developed normally, but showed deficits in learning behavior. Therefore, it is suggested that eEF1BdeltaL is involved in the brain function especially learning and memory in the adulthood.
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Research Products
(6 results)
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[Journal Article] High Oxygen Condition Facilitates the Differentiation of Mouse and Human Pluripotent Stem Cells into Pancreatic Progenitors and Insulin-Producing Cells2014
Author(s)
Hakim, F., Kaitsuka, T., Mohd Raeed, J., Wei, F.Y., Shiraki, N., Akagi, T., Yokota, T., Kume, S., and Tomizawa, K.
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Journal Title
J. Biol. Chem.
Volume: 289
Pages: 9623-9638
DOI
Peer Reviewed
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[Journal Article] Generation of functional insulin-producing cells from mouse ES cells through 804G cell-derived extracellular matrix and protein transduction of transcription factors2013
Author(s)
Kaitsuka, T., Noguchi, H., Shiraki, N., Kubo, T., Wei, FY., Hakim, F., Kume, S., and Tomizawa, K.
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Journal Title
Stem Cells Transl. Med.
Volume: 3
Pages: 114-27
DOI
Peer Reviewed
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[Journal Article] Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus2012
Author(s)
Ueda, Y., Wei, F.Y., Hide, T., Michiue, H., Takayama, K., Kaitsuka, T., Nakamura, H., Makino, K., Kuratsu, J., Futaki, S., Tomizawa, K.
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Journal Title
Biomaterials
Volume: 33
Pages: 9061-9069
DOI
Peer Reviewed
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