Roles of secretin-oxytocin system in the control of social recognition/ memory.

2013 Fiscal Year Final Research Report

• Project/Area Number: 24790236
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Jichi Medical University
• Principal Investigator: TAKAYANAGI Yuki 自治医科大学, 医学部, 講師 (10418890)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: オキシトシン / セクレチン / 社会的記憶 / 視索上核 / 内側扁桃体

Research Abstract

Secretin activated oxytocin neurons of the supraoptic nucleus and facilitated oxytocin release centrally. Local application of secretin into the supraoptic nucleus facilitated social recognition/ memory. The facilitative effects of secretin upon social recognition/ memory were inhibited by an oxytocin receptor antagonist injected into the medial amygdala or in oxytocin receptor-deficient mice. Furthermore, oxytocin treatment restored social recognition/ memory in secretin receptor-deficient mice. All these results suggest that newly defined secretin-oxytocin system plays a critical role in regulating social memory/ recognition.

Research Products

• [Journal Article] オキシトシン、ウロコルチン (2014)
  • Author(s): 高柳友紀、尾仲達史
  • Journal Title: 日本臨牀 増刊号 最新肥満症学─ 基礎・臨床研究の最前線─ Volume: 1059 Pages: 224-23
• [Journal Article] Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice (2013)
  • Author(s): Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So KH, Kawada T, Inoue N, Ikeda I, Roh SG, Itoi K, Nishimori
  • Journal Title: Endocrinology Volume: 154 Pages: 4305-4315
  • DOI: 10.1210/en.2012-2206
  • Peer Reviewed
• [Journal Article] Involvement of prolactin-releasing peptide in the activation of oxytocin neurones in response to food intake (2013)
  • Author(s): Yamashita M, Takayanagi Y, Yoshida M, Nishimori K, Kusama M, Onaka T
  • Journal Title: Journal of neuroendocrinology Volume: 25 Pages: 455-465
  • DOI: 10.1111/jne.12019
  • Peer Reviewed
• [Journal Article] 母性行動と下垂体ホルモン (2013)
  • Author(s): 尾仲達史、高柳友紀
  • Journal Title: 精神科治療学 Volume: 28 Pages: 777-7
• [Journal Article] The medial amygdala – medullary PrRP-synthesizing neuron pathway mediates neuroendocrine responses to contextual conditioned fear in male rodents
  • Author(s): Yoshida M, Takayanagi Y, Onaka T
  • Journal Title: Endocrinology Volume: (in press)
  • Peer Reviewed
• [Presentation] 社会的記憶の制御におけるセクレチンーオキシトシンシステムの役割 (2014)
  • Author(s): 高柳友紀
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学(鹿児島)
  • Year and Date: 2014-03-17
• [Presentation] 下垂体後葉ホルモンとストレス・摂食・社会行動.創薬薬理フォーラム (2013)
  • Author(s): 尾仲達史
  • Organizer: 第21回シンポジウム
  • Place of Presentation: 長井記念館(東京)
  • Year and Date: 2013-09-19
  • Invited
• [Presentation] The medial amygdalamedullary prolactin- releasing peptide neuron pathway mediates neuroendocrine responses to conditioned fear stimuli. (2013)
  • Author(s): Yoshida M
  • Organizer: 10^<th> World Congress on Neurohypophysial Hormones (WCNH 2013)
  • Place of Presentation: ST George's Bristol (Bristol, UK)
  • Year and Date: 2013-07-18
• [Presentation] 恐怖記憶の想起による神経内分泌反応には内側扁桃体−延髄PrRP産生ニューロン経路が関与する (2013)
  • Author(s): 吉田匡秀
  • Organizer: 第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会 合同大会(Neuro2013)
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2013-06-22
• [Presentation] エネルギー代謝とストレスにおけるPrRP−オキシトシン系の働き (2012)
  • Author(s): 高柳友紀
  • Organizer: 第39回日本神経内分泌学会学術集会
  • Place of Presentation: 北九州国際会議場(福岡)
  • Year and Date: 2012-09-28
  • Invited
• [Book] Advances in Cognitive Neurodynamics (III) (2013)
  • Author(s): Wang Y, Takayanagi Y, Onaka T
  • Total Pages: 753-757
  • Publisher: Springer
• [Remarks]
  • URL: http://www.jichi.ac.jp/usr/pys1/admnpys1/index.html