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2013 Fiscal Year Final Research Report

Neural mechanism of age-related decline in circadian rhythmicity

Research Project

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Project/Area Number 24790238
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionTeikyo Heisei University

Principal Investigator

NAKAMURA Takahiro  帝京平成大学, 薬学部, 講師 (00581985)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords生体リズム / 加齢 / 神経回路 / 視床下部 / 視交叉上核 / 時計遺伝子 / 電気生理
Research Abstract

Aging is associated with changes in sleep amount, sleep quality, and specific sleep pathologies and disorders in humans. The dysfunction of the central circadian oscillator (SCN; suprachiasmatic nucleus of the hypothalamus in mammals) is recognized as one of the central causes of age-related sleep disturbances. However, it is still unclear how the SCN become senescent. In this study, we investigated to discover age-related molecules in the mouse SCN by means of DNA microarray. In the result, we found some molecules that the amount of expression increased or decreased in the aged SCN. If it is confirmed that these molecules contribute to the dysfunction of SCN, it would be a candidate for new treatment strategies for sleep disturbances in the aging population and would potentially improve the quality of life for aged individuals.

  • Research Products

    (13 results)

All 2014 2013 2012 Other

All Journal Article (6 results) Presentation (5 results) Book (1 results) Remarks (1 results)

  • [Journal Article] TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages2014

    • Author(s)
      Goto Y, Ogawa K, Nakamura TJ, Hattori A, Tsujimoto M
    • Journal Title

      Journal of immunology (Baltimore, Md. : 1950)

      Volume: 192 Pages: 4443-4452

    • DOI

      10.4049/jimmunol.1300935

  • [Journal Article] 体内時計概論2014

    • Author(s)
      中村孝博,中村渉
    • Journal Title

      あたらしい眼科

      Volume: 31 Pages: 191-198

  • [Journal Article] 加齢による概日リズム機能低下の神経機構2013

    • Author(s)
      中村孝博
    • Journal Title

      薬事日報(医療と薬剤)

      Volume: 秋号 Pages: 18-19

  • [Journal Article] 体内時計の加齢変化2013

    • Author(s)
      中村渉,中村孝博
    • Journal Title

      アンチ・エイジング医学

      Volume: 9(2) Pages: 222-230

  • [Journal Article] Effects of age-related dopaminergic neuron loss in the substantia nigra on the circadian rhythms of locomotor activity in mice2012

    • Author(s)
      Tanaka M, Yamaguchi E, Takahashi M, Hashimura K, Shibata T, Nakamura W, Nakamura TJ
    • Journal Title

      Neuroscience research

      Volume: 74 Pages: 210-5

    • DOI

      10.1016/j.neures.2012.09.005

  • [Journal Article] Neural Circuits Underlying Circadian Oscillations in Mammals : Clocks in a Dish, Isolated Central Nervous System Circuits2012

    • Author(s)
      Nakamura TJ, Michel S, Block GD, Colwell CS
    • Journal Title

      Neuromethods

      Volume: 73 Pages: 183-210

    • DOI

      10.1007/978-1-62703-020-5_5

  • [Presentation] 生後24時間以内のethinyl estradiol曝露は成熟後の脳内ERα発現量を減少させる2013

    • Author(s)
      志賀健臣,中村孝博,小峰千亜希,神島愛未,後藤芳邦,吉田緑,近藤保彦,溝口康,川口真以子
    • Organizer
      第16回日本内分泌かく乱化学物質学会研究発表会
    • Place of Presentation
      東京大学山上会館、東京
    • Year and Date
      20131212-13
  • [Presentation] 加齢によってマウス視交叉上核で変化する分子の探索2013

    • Author(s)
      南景子,中村渉,中村孝博
    • Organizer
      第20回日本時間生物学会学術大会
    • Place of Presentation
      近畿大学、東大阪市
    • Year and Date
      20131109-10
  • [Presentation] マウス顎下腺の時計遺伝子,時計制御遺伝子と機能分子mRNAの概日リズム2013

    • Author(s)
      内田仁司,中村孝博,阪井丘芳,中村渉
    • Organizer
      第20回日本時間生物学会学術大会
    • Place of Presentation
      近畿大学、東大阪市
    • Year and Date
      20131109-10
  • [Presentation] 加齢による概日リズム機能低下の神経機構2012

    • Author(s)
      中村孝博
    • Organizer
      第19回日本時間生物学会学術大会
    • Place of Presentation
      北海道大学、札幌市
    • Year and Date
      20120915-16
  • [Presentation] 加齢による概日リズム機能低下の神経機構2012

    • Author(s)
      中村孝博,中村渉
    • Organizer
      第13回日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      20120628-30
  • [Book] トランスジェニック・ノックアウトマウスの行動解析(翻訳本;共訳者:高瀬堅吉、柳井修一、他11名;担当:第二章ユニコーンとキメラ2012

    • Author(s)
      中村孝博
    • Total Pages
      407(ページ7-25)
    • Publisher
      西村書店
  • [Remarks] <ホームページ>

    • URL

      http://researchmap.jp/tjnakamura/

URL: 

Published: 2015-06-25  

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