2013 Fiscal Year Final Research Report

Alterations in reproductive neuroendocrine system of a rat model of polycystic ovary syndrome

Research Project

Project/Area Number	24790240
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Nippon Medical School
Principal Investigator	IWATA kinuyo 日本医科大学, 医学部, 助教 (00582991)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	キスペプチン / 多嚢胞性卵巣症候群 / アンドロゲン / 黄体形成ホルモン / 脳 / 生殖
Research Abstract	Expression of kisspeptin in the brain and luteinizing hormone (LH) levels in the plasma were examined in androgen-induced polycystic ovary syndrome (PCOS) model rats. Kisspeptin expression and LH pulses associated with follicular development were suppressed in PCOS model rats. Although kisspeptin associated with ovulation was unaffected by androgen, GnRH administration could not induce LH release in PCOS rats, resulting in a suppression of LH surge. Hence, hyperandrogenism in women with PCOS may be associated with anovulation and menstrual irregularity by adversely affecting kisspeptin neurons and the pituitary.

(4 results)