2013 Fiscal Year Final Research Report
The role of the vasopressin neuron in the suprachiasmatic nucleus for circadian rhythm
| Project/Area Number |
24790243
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Research Collaborator |
UETA Yoichi 産業医科大学, 医学部, 教授 (10232745)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | サーカディアンリズム / バゾプレッシン / 視交叉上核 / GABA |
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| Research Abstract |
Arginine vasopressin (AVP) is well known as a peptide concern to adjust body fluid and blood pressure. AVP neuron is also located in the dorsomedial parts of the suprachiasmatic nucleus (SCN) which is the central circadian rhythm generator and considered to have some role in generating circadian rhythm. We used the AVP-eGFP transgenic rat and investigated the electrophysiological property of AVP neuron in the SCN. Our study showed that AVP neurons response to GABA are different in case of dissociated time. It is possible that AVP neuron in the SCN has a electrophysiological circadian rhythm that depends on intracellular chloride ion concentration.
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Research Products
(1 results)
