2013 Fiscal Year Final Research Report
Relationship between diabetes and epigenetic modification regulated by ketone body metabolism
| Project/Area Number |
24790244
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
UEBANSO Takashi 徳島大学, ヘルスバイオサイエンス研究部, 助教 (10581829)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 糖尿病 / エピゲノム / ケトン体 |
|---|
| Research Abstract |
I studied relationship between deiabetes and epigenome modification regulated by ketone body metabolism. Knock down of one of two enzyme which metabolise ketone body affect methylation of histone H3. Moreover, disruption of ketone body metabolism affect stress induced cytotoxicity in pancreatic beta cells. These results suggest that ketone body metabolism link epigenenome modification and cellular function.
|
