2013 Fiscal Year Final Research Report
The role of pain-induced dopamine release within the nucleus accumbens in pain-induced aversion
| Project/Area Number |
24790245
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Hokkaido University |
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Principal Investigator |
IDE Soichiro 北海道大学, 薬学研究科(研究院), 助教 (30389118)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 痛み / 情動 / 嫌悪 / 側坐核 / ドパミン / 不快情動 |
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| Research Abstract |
In the present study, we examined the role of pain-induced dopamine release within the nucleus accumbens in pain-induced aversion. A significant increase in the dopamine level was observed after the formalin injection only within the rostral part of the nucleus accumbens shell but not within the caudal part. The conditioned place aversion (CPA) induced by the i.pl. formalin injection was reversed by the microinjection of dopamine D2 antagonist into the rostral part of the nucleus accumbens shell. On the other hand, the microinjection of dopamine D2 agonist into the same region did not induce the CPA.
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