2013 Fiscal Year Final Research Report

Physiological characterization of GPR120 in lung

Research Project

Project/Area Number	24790249
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General pharmacology
Research Institution	Kyoto University
Principal Investigator	HARA Takafumi 京都大学, 医学(系)研究科(研究院), 助教 (90546722)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	Lung / Fatty acid / GPCR
Research Abstract	GPR120 is one of the fatty acid-activated receptors. GPR120 expressed in adipose tissue and intestine is known to act as the differentiation of adipocytes and incretin hormone secretion, respectively. On the other hand, the function of GPR120 expressed in lung tissue remain to be clarified. Surfactant proteins that is necessary to the expansion and contraction of alveolus during respiration fatty acids are one of the content molecule. Our results using the GPR120 KO mice indicated that GPR120 is expressed surfactant secretion cells and might regulate surfactant secretion.

(1 results)