2013 Fiscal Year Final Research Report
Pharmacological elucidation of the cellular and molecular mechanisms in drug-induced nephrotoxicity and the prevention.
| Project/Area Number |
24790255
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
YANO TAKAHISA 九州大学, 大学病院, その他 (90532846)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 腎障害 / バンコマイシン / アポトーシス / ミトコンドリア / 活性酸素種 / MAPK / JNK |
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| Research Abstract |
Anti-MRSA drug vancomycin (VCM) caused the mitochondrial-mediated reactive oxygen species (ROS) generation leading to a concentration- and time-dependent cell apoptosis in cultured renal tubular LLC-PK1 cells. A lipophilic antioxidant vitamin E and a mitochondria-targeted antioxidant mitoTEMPO significantly prevented the VCM-induced mitochondrial dysfunction and apoptosis. VCM also caused phosphorylation of JNK, while a JNK inhibitor SP600125 showed a significant suppression against the VCM-induced cell injury.
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