Identification of factors involved in retinal circulation dysfunction and exploration therapeutic drugs that improve disorders of retinal circulation.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790261
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Kitasato University
• Principal Investigator: MORI Asami 北里大学, 薬学部, 助教 (80453504)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 薬理学 / 微小循環 / 緑内障 / 糖尿病 / 血管生物学 / 網膜 / 内皮由来過分極因子 / beta アドレナリン受容体

Outline of Final Research Achievements

This study suggested that the candidate mediator for endothelium-deriverd hyperpolarizing factor (EDHF) in retinal blood vessels may be epoxyeicosatrienoic acid. Moreover, in retinal blood vessels, gap junction has been played a key role in EDHF-mediated vasodilation. Furthermore, our study suggested that increased oxidative stress, such as 4-hydroxy-2-nonenal, in retinal blood vessels and retinal neuronal cells of diabetes and glaucoma rats may be an important mechanism responsible for impairment of the vasodilator mechanisms in retinal blood vessels. In conclusion, potent antioxidative drugs may be novel candidates for prevention and/or treatment of glaucoma and diabetic retinopathy.

Free Research Field

薬理学