2013 Fiscal Year Final Research Report
Dynamic regulation of cell differentiation via gene regulatory networks organized by multiple transcription factors
| Project/Area Number |
24790271
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
OCHIAI Kyoko 東北大学, 医学(系)研究科(研究院), 助教 (10455785)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 遺伝子発現制御 |
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| Research Abstract |
Cell type specific transcription factor (TF) regulate cell differentiation via the organization of gene regulatory network (GRN). The aim of this research is focused on the chain reaction of GRNs caused by two different TFs, which have the relation of up- and downstream. The GRN organized by FoxO1, the upstream TF, have been clarified in our previous study. The GRNs organized by the downstream TF, which are the direct target of FoxO1 and activated via FoxO1-GRN, have analyzed. Our new GRNs model will present the molecular mechanism for promoting cell differentiation via multiple TFs.
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