2013 Fiscal Year Final Research Report
Analysis of vitamin K functions on age-related diseases using organ-specific gene knockout mice.
| Project/Area Number |
24790273
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AZUMA Kotaro 東京大学, 医学部附属病院, 特任講師 (30401110)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ビタミンK / 老化 / 遺伝子 / 蛋白質 |
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| Research Abstract |
In this study, we were able to obtain many insights concerning extra-hepatic function of vitamin K by generating neural cell- and osteoblast-specific gamma-glutamyl carboxylase (GGCX) knockout mice and osteoblast- and osteoclast-specific pregnane X receptor (PXR) knockout mice. In addition, we discovered candidates of GGCX substrates in nueral cells, and two long non-coding RNAs induced by agonists of steroid and xenobiotic receptor (human ortholog of PXR) in an osteoblastic cell line.
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[Journal Article] Liver-specificγ-glutamyl carboxylase-1 deficient mice display bleeding diathesis and short life span2014
Author(s)
Azuma K, Tsukui T, Ikeda K, Shiba S, Nakagawa K, Okano T, Urano T, Horie-Inoue K, Ouchi Y, Ikawa M, Inoue S
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Journal Title
PLoS ONE
Volume: 9
Pages: e88643
DOI
Peer Reviewed
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