2014 Fiscal Year Final Research Report
Molecular analysis of TMEM16 family members
| Project/Area Number |
24790278
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
SUZUKI Jun 京都大学, 医学(系)研究科(研究院), 助教 (30511894)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | TMEM16F / TMEM16 / Xkr8 / Xkr / Scramblase / リン脂質スクランブリング / ホスファチジルセリン / アポトーシス |
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| Outline of Final Research Achievements |
Phospholipids are asymmetrically distributed in plasma membrans. However, its distribution is disrupted by phospholipid scramblases, which transport lipids bidirectionally and nonspecifically. In this study, I investigated molecular functions of TMEM16 family members, and found that TMEM16C, D, F, G, and J possessed phospholipid scrambling activity.
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| Free Research Field |
膜脂質学
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