2013 Fiscal Year Final Research Report
Study of mitochondrial behavior as a sensor of surrounding conditions during cell proliferation and differentiation.
| Project/Area Number |
24790289
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ミトコンドリア / 環境センシング / 細胞増殖 / 細胞分化 / ミトコンドリアダイナミクス |
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| Research Abstract |
Although we could not get any direct evidences that mitochondria might sense the surrounding conditions by monitoring the changes of ATP or Ca2+ concentrations within individual mitochondria, we found that mitochondria chenged their morphologies in response to the glucose starvation. We investigated the molecular mechanisms underlying glucose starvation-induced mitochondrial morphological changes and we could identify AMPK as a key molecule for that regulation. AMKP is well known kinase that is activated by luck of energy, suggesting that AMPK acts as a sensor for mitochondria. Altogether, mitochondria might sense the sorrounding conditions through AMPK, so we are now challenging to identify the novel substrates for AMPK that localizes in/on mitochondria.
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