2013 Fiscal Year Final Research Report
Role of Nrf2 in compensatory liver proliferation after portal vein branch ligation in mice
| Project/Area Number |
24790307
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TAGUHI Keiko 東北大学, 加齢医学研究所, 助教 (20466527)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | Nrf2 / 肝臓 / 増殖 |
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| Research Abstract |
Hepatectomy is a standard therapy in liver cancer patients. Massive hepatectomy is possible to lead to liver failure. Portal vein embolization increases liver size and reduces complications. Therefore, portal vein embolization is accepted before hepatectomy to prevent liver failure. Molecular mechanisms in portal vein embolization remain elusive. In this study, portal vein branch ligation is performed in mice. We found that a transcription factor Nrf2 contributes to liver proliferation. Further more, a pre-treatment of an Nrf2 activator accelerates liver hypertrophy after portal vein branch ligation. An Nrf2 activator may be effective for enhancement of hypertrophy after portal vein embolization in liver cancer patients.
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Research Products
(41 results)
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[Journal Article] Keapl inhibition attenuates glomerulosclerosis2014
Author(s)
Miyazaki Y, Shimizu A, Pastan I, T Taguchi K, Naganuma E, Suzuki T, Hosoya T, Yokoo T, Saito A, Miyata T, Yamamoto M, Matsusaka T
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Journal Title
Nephrol Dial Transplant
Volume: 29(4)
Pages: 783-791
Peer Reviewed
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[Journal Article] The circadian clock regulates rhythmic activation of the NRF2/glutathione - mediated antioxidant defense pathway to modulate pulmonary fibrosis2014
Author(s)
Pekovic, Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GT, Fukada Y, and Meng AJ.
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Journal Title
Genes Dev
Volume: 28(6)
Pages: 548-560
Peer Reviewed
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[Journal Article] The role of the Nrf2 - mediated defense system in corneal epithelial wound healing2013
Author(s)
Hayashi R, Himori N, Taguchi K, Ishikawa Y, Uesugi K, Ito M, Duncan T, Tsu j ikawa M, Nakazawa T, Yamamoto M, Nishida K
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Journal Title
Free Radic Biol Med
Volume: 61C
Pages: 333-342
Peer Reviewed
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[Journal Article] Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress - induced liver injury in nutritional steatohepatitis2012
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M, Tokushige K, Ueda T, Harada N, Taguchi K, Hashimoto E, Itoh K, Ishii T, Utsunomiya H, Yamamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 47(8)
Pages: 924-935
Peer Reviewed
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[Journal Article] Metabolic stress response implicated in diabetic retinopathy : the role of calpain, and the therapeutic impact of calpain inhibitor2012
Author(s)
Shanab AY, Nakazawa T, Ryu M, Tanaka Y, Himori N, Taguchi K, Yasuda M, Watanabe R, Takano J, Takaomi S, Minegishi N, Miyata T, Abe T, Yamamoto M
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Journal Title
Neurobiol Dis
Volume: 48(3)
Pages: 556-567
Peer Reviewed
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[Presentation] Reciprocal activation between Nrf2 and a proliferative signaling in liver2012
Author(s)
16. Keiko Taguchi, Hozumi Motohashi, Masayuki Yamamoto
Organizer
Kumamoto University Core Research Project B "Center for Frontier Research on Life Style an Stress Signal" and Grants-in-Aid for Scientific Research on Innovative Areas(Research in a Proposed Research Area), MEXT, Japan "Signaling Functions of Reactive Oxygen Species" Joint Symposium
Place of Presentation
Kumamoto
Year and Date
2012-12-18
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