2014 Fiscal Year Final Research Report
The search for myokines in mouse model of hypertrophy.
| Project/Area Number |
24790330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Fujita Health University |
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Principal Investigator |
NAKATANI Masashi 藤田保健衛生大学, 総合医科学研究所, 助教 (00421264)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | マイオスタチン / プロテオミクス / 骨格筋 |
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| Outline of Final Research Achievements |
Myostatin is a potent negative regulator of skeletal muscle. In this study, we find the myokines from myostatin deficient mouse. Muscle and serum from MSTN(-/-) mouse were purified any methods. Muscle purified was difficult, because muscle was including any actin and myosin. Serum from MSTN(-/-) was purified two affinity columns. The result of purified, we found a bone related molecule. The femur of Bone mineral density in MSTN(-/-) mouse was increased.
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| Free Research Field |
生化学
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