2013 Fiscal Year Final Research Report
Evaluation of a role of SIK3 on immune system and screening of novel anti-inflammatory molecules
| Project/Area Number |
24790333
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | 独立行政法人医薬基盤研究所 |
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Principal Investigator |
SANOSAKA Masato 独立行政法人医薬基盤研究所, 創薬基盤研究部, 特任研究員 (30510515)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 分子病態学 |
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| Research Abstract |
SIK3-KO mice exhibit excessive liver injury accompanied with the secretion of pro-inflammatory molecules. This observation is suggested the activation of macrophages. In order to discover a novel strategy to control an inflammation, we evaluated the properties of macrophages prepared from SIK3-KO mice. SIK3-KO macrophages secrete the specific inflammatory molecules compared to wild type mice.
Furthermore, we identified pterosin as a SIK3-inhibitor. Pterosin inhibited inflammation of macrophages and it was suggested that pterosin is a new anti-inflammatory molecules.
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[Journal Article] Involvement of SIK3 in glucose and lipid homeostasis in mice2012
Author(s)
①Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveira A, Bertorello AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H
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Journal Title
PLoS One
Volume: 7(5)
Pages: e37803
Peer Reviewed
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