2013 Fiscal Year Final Research Report
The functional analysis of histone methyltransferase in obesity
| Project/Area Number |
24790334
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human genetics
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| Research Institution | Juntendo University (2013)
The University of Tokyo (2012) |
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Principal Investigator |
FUJII Tomoaki 順天堂大学, 医学(系)研究科(研究院), 研究員 (10511420)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | エピジェネティクス / ヒストンメチルトランスフェラーゼ / 肥満 |
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| Research Abstract |
Accumulating findings show that histone methyltransferases are implicated in obesity.To investigate the role of Smyd family genes encode histone methyltransferase, we generated and analyzed Smyd2/3double knockout mice. The mice exhibited obesity related phenotypes, an increase in body weight and abnormal accumulation of fat. These results suggest that Smyd2 and Smyd3 play a significant role in fat accumulation and adipocyte differentiation.
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Research Products
(6 results)
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[Journal Article] Overexpression of Cohesion Establishment Factor DSCC1 through E2F in Colorectal Cancer2014
Author(s)
②Yamaguchi, K., Yamaguchi, R., Takahashi, N., Ikenoue, T., Fujii, T., Shinozaki, M., Tsurita, G., Hata, K., Niida, A., Imoto, S., Miyano, S., Nakamura, Y., Furukawa, Y
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Journal Title
PLoS ONE
Volume: 9(1)
Pages: e85750
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