Develompent of the diagnostic method for Lewy body disease. Accumulation of prostease-resistant alpha-synuclein in the skin.

2013 Fiscal Year Final Research Report

• Project/Area Number: 24790348
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: The University of Tokyo
• Principal Investigator: IKEMURA Masako 東京大学, 医学部附属病院, 助教 (80524553)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: パーキンソン病 / レビー小体病 / 皮膚生検 / α-シヌクレイン

Research Abstract

Lewy bodies (LBs) containing alpha-synuclein are the hallmark lesions of Lewy body disease, including Parkinson disease (PD), PD with dementia, dementia with LBs and pure autonomic failure. Since protease treatment is known to enhance the immunoreactivity of abnormal alpha-synuclein, we immunohistochemically examined the abdominal skin tissue in LBD using anti-alpha-synuclein antibody with protease treatment. Protease-resistant alpha-synuclein is depositd in nerve fascicles mainly around blood vessels in LBD, but not in control subjects. The sensitivity of the positive skin immunoreactivity was 57.7% in subclinical PD, 88.2% in PD and PD with dementia and 53.8% in dementia with LBs. The sensitivity is higher than that using anti-phosphorylated alpha-synuclein antibody. Skin biopsy with ant-alpha-synuclein antibody may have diagnostic application in cases of LBD.

Research Products

• [Journal Article] Plexiform angiomyxoid myofibroblastic tumor (PAMT) of the stomach. A case report focusing on its characteristic growth pattern (2014)
  • Author(s): Ikemura M, Maeda E, Hatao F, Aikou S, Seto Y, Fukayama M
  • Journal Title: Int J Clin Exp Pathol Volume: 7 Pages: 685-689
  • Peer Reviewed
• [Journal Article] 中縦隔嚢胞を示した甲状腺乳頭癌右気管傍リンパ節転移の1例 (2013)
  • Author(s): 福井梨紗,村川知弘,此枝千尋,井上雄太,日野春秋,一瀬淳二,北野健太郎,長山和弘,安樂真樹,池村雅子,木村百合香,中島淳
  • Journal Title: 胸部外科 Volume: 66 Pages: 1109-1112
  • Peer Reviewed
• [Journal Article] Two cases with hepatic amyloidosis suspected of having primary sclerosing cholangitis (2013)
  • Author(s): Hirano K, Ikemura M, Mizuno S, Isayama H, Watanabe T, Saito T, Kawahata S, Ushino R, Hamada T, Miyabayashi K, Sasaki T, Kogure H, Yamamoto N, Sasahira N, Koike K, Fukayama M, Sugawara Y, Kokudo N
  • Journal Title: Hepatol Res Volume: 43 Pages: 911-916
  • DOI: 10.1111/hepr.12034
  • Peer Reviewed
• [Journal Article] The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement (2012)
  • Author(s): Ishiura H, Sako W, Yoshida M, Kawarai T, Tanabe O, Goto J, Takahashi Y, Date H, Mitsui J, Ahsan B, Ishikawa Y, Iwata A, Yoshino H, Izumi Y, Fu j ita K, Maeda K, Ikemura M, et al
  • Journal Title: Am J Hum Genet Volume: 91 Pages: 320-329
  • DOI: 10.1016/j.ajhg.2012.07.014
  • Peer Reviewed
• [Presentation] 左室補助人工心臓(LVAD)装着剖検例における脳血管障害の病理学的検討 (2013)
  • Author(s): 池村雅子,木下修,木村光利,絹川弘一郎,小野稔,村山繁雄,深山正久
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20130606-08
• [Presentation] 特徴的病理像を呈した髄膜炎の一剖検症例 (2013)
  • Author(s): 池村雅子,田中麻理子,松坂恵介,山本和孝,清水潤,辻省次,深山正久,村山繁雄
  • Organizer: 第54回日本神経病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 20130424-26
• [Presentation] 突然死の1剖検例 (2012)
  • Author(s): 池村雅子,田中淳,東浩太郎,深山正久
  • Organizer: 日本病理学会秋期特別総会
  • Place of Presentation: 名古屋
  • Year and Date: 20121122-23
• [Presentation] 脊髄に発生したglioneuronal tumor with neuropil-like islands の一例 (2012)
  • Author(s): 池村雅子,篠崎綾,今井英明,石井一彦,齊藤邦昭,武笠晃丈,斉藤延人,柴原純二,深山正久
  • Organizer: 日本脳腫瘍病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 20120524-26
• [Presentation] 魅力あるCPCの工夫院内CPCスライド公開,CPCeラーニングの試み (2012)
  • Author(s): 池村雅子,高澤豊,深山正久
  • Organizer: 日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 20120426-28