2014 Fiscal Year Final Research Report
Molecular pathological approach to follicular lymphoma stem-like cells
| Project/Area Number |
24790350
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 悪性リンパ腫 |
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| Outline of Final Research Achievements |
We investigated several stem-like phenotype markers in follicular lymphoma patient samples, and some minor population was positive for these stem-like markers. These cells harbored t(14;18) by microdissection study. Furthermore, some minor stem-like positive cells presented in human derived B-cell lymphoma cell lines and these minor populations had treatment resistance and strong tumorigenic potential by in vitro and in vivo assay.
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| Free Research Field |
人体病理学
|
