2013 Fiscal Year Final Research Report
An establishment of novel mouse-model of intraductal tubulopapillary neoplasm of the pancreas
| Project/Area Number |
24790358
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 膵管内管状乳頭腫瘍 / 膵癌 / 遺伝子改変マウス |
|---|
| Research Abstract |
Intraductal tubulopapillary neoplasm (ITPN) is a new entity of pancreatic cancer. Although molecular abnormalities implicated in the oncogenesis of ITPNs are still unclear, PIK3CA mutation may play an important role in oncogenesis of ITPNs based on our previous research.
In the present study, we established a novel mouse-model using Cre-LoxP system, in which PIK3CA-mutations were specifically induced in the pancreas. At present, pancreata of mice at 12 to 28 weeks were microscopically investigated in detail. Any pancreatic neoplasms including ITPN-like tumor have not been observed in their pancreata but three cases showed acinar to ductal metaplasia. ITPNs in human are similar to pancreatic ductules in morphological and immunohistochemical levels. Because pancreatic ductule is one of the main components of acinar to ductal metaplasia, it is very interesting that acinar to ductal metaplasia was observed in some cases of our model. Our study is still ongoing.
|
