2014 Fiscal Year Final Research Report
A combination of nuclear beta-catenin and atypical scores as useful diagnostic markers for borderline malignancy of gastric tumours.
| Project/Area Number |
24790361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Research Collaborator |
SAEGUSA Makoto
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | β-カテニン / 胃良悪性境界病変 / 病理組織診断 |
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| Outline of Final Research Achievements |
Although recent advances in endoscopic technology, including submucosal dissection (ESD), contribute to significant improvement in detection and treatment for early gastric carcinomas (GCas), discrepant diagnosis between forceps biopsied and ESD sections sometimes occurs. Here, we focused on histological markers for accurate diagnosis of gastric tumours in forceps biopsied samples before ESD treatment.
In conclusion, the present study provided evidence that a combination of nuclear β-catenin and atypical scores which were evaluated according to degree of nuclear pseudostratification and number of branching features which were evaluated by nuclear and structural abnormalities may be useful for differential diagnosis of borderline malignancy of gastric tumours, even in forceps biopsied samples before ESD treatment.
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| Free Research Field |
消化管病理
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