2013 Fiscal Year Final Research Report

Study of molecular pathology of salivary gland tumor

Research Project

Project/Area Number	24790369
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Human pathology
Research Institution	National Center of Neurology and Psychiatry
Principal Investigator	OHTOMO Rie 独立行政法人国立がん研究センター, 中央病院, 外来研究員 (50626322)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	唾液腺腫瘍 / SOX10 / 病理診断
Research Abstract	Salivary gland tumors are relatively rare and morphologically diverse and heterogeneous tumors; therefore, histogenesis-based tumor markers are sorely needed to aid in diagnosing and determining the cell type of origin. SOX10 protein is a transcription factor known to be crucial in the specification of the neural crest. In addition, positive expression has also been implicated in the major salivary gland. SOX10 expression clearly delineated two distinct subtypes of human salivary gland tumors. In normal human salivary gland tissue, SOX10 expression was specific to the nuclei of acini and both luminal and abluminal cells of intercalated ducts but not in other sites. Moreover, the murine model suggested that SOX10 continued to be expressed from the developmental stage to adulthood in the acinar and both luminal and abluminal intercalated ducts in the major salivary gland. Thus, SOX10 is a novel marker for diagnosing and understanding the histogenesis of salivary gland tumors.

(2 results)