Analysis of Wnt5a-Ror signaling in renal fibrosis

2013 Fiscal Year Final Research Report

• Project/Area Number: 24790385
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: University of Occupational and Environmental Health, Japan (2013); Kobe University (2012)
• Principal Investigator: YAMAGATA Kaoru 産業医科大学, 医学部, 助教 (80533786)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: Ｗｎｔ５ａ / Ｒｏｒ２ / ＵＵＯ / ＭＭＰ－２ / 腎不全 / 腎線維化 / 基底膜破壊

Research Abstract

Expression of receptor tyrosine kinase Ror2 is induced in the affected kidneys of UUO model mice by western blotting. Further, MMP-2, involved in disruption of basement membrane, is induced in Ror2-positive renal epithelial cells by immunofluorescence. Expectedly, disrupted basement membrane is observed in the neighborhood of Ror2-positive cells, indicating crucial role of Wnt5a-Ror2 signaling in the progression of renal malfunction.

Research Products

• [Journal Article] Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells during renal fibrosis (2013)
  • Author(s): K. Yamagata, X. Li, M. Nishita, M. Endo, N. Arfian, Y. Rikitake, N. Emoto, K-I. Hirata, Y. Tanaka, Minami Y
  • Journal Title: Genes Cells Volume: 18 Pages: 608-19
  • Peer Reviewed
• [Journal Article] The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells
  • Author(s): S. Kubo, K. Yamaoka, M. Kondo, K. Yamagata, J. Zhao, S. Iwata, Y. Tanaka
  • Journal Title: Ann. Rheum. Dis Volume: (in press)
  • Peer Reviewed
• [Presentation] Analysis of Wnt5a-Ror signaling in renal fibrosis using a mouse model (2012)
  • Author(s): Yamagata K, Li X, Nur A, Endo M, Rikitake Y, Emoto N, Nishita M, Minami Y
  • Organizer: The 3rd GCOE International Symposium on Signal Transduction Medicine in the Coming Generation
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-10
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/medzoo/