2017 Fiscal Year Final Research Report
The role of direct targets of ASPL-TFE3 in the pathology of alveolar soft part sarcoma
| Project/Area Number |
24790387
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Research Collaborator |
YOSHIDA Haruhiko
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| Project Period (FY) |
2013-02-01 – 2018-03-31
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| Keywords | 軟部腫瘍 / 病態解析 / 融合遺伝子 |
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| Outline of Final Research Achievements |
In this study, we investigated the role of target genes of ASPL-TFE3 chimeric oncogene in the tumorigenesis and pathogenesis of alveolar soft part sarcoma. We identified p21 and a signaling molecule as direct transcriptional targets of ASPL-TFE3. Our results showed that ASPL-TFE3 induced cellular senescence and the expression of pro-inflammatory cytokines associated with the SASP by upregulating p21 expression. Furthermore, we found that ASPL-TFE3 lead to the inappropriate activation of signal transduction pathway and the promotion of cell motility by upregulating signaling molecule. These results suggest that ASPL-TFE3 contribute to pathogenesis and progression of alveolar soft part sarcoma by inducing aberrant expression of transcriptional targets implicated in cellular senescence and signal transduction mechanisms.
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| Free Research Field |
実験病理学
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