2013 Fiscal Year Final Research Report

Study for relationship between CAMDI function in cortical lamination and psychiatric disorders

Research Project

Project/Area Number	24790392
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Experimental pathology
Research Institution	Tokyo University of Pharmacy and Life Science
Principal Investigator	FUKUDA Toshifumi 東京薬科大学, 生命科学部, 講師 (50372313)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	CAMDI / 脳 / 発生
Research Abstract	We identified a novel disrupted in schizophrenia 1 (DISC1)-associate protein, named CAMDI. CAMDI knock-down experiment by sh-RNA using in utero electroporation revealed severely impairment of radial migration with disoriented centrosomes. The CAMDI gene knockout mice revealed an abnormal neuronal migration, short dendrite and high spine density at the cerebrum. The cerebrum is known as a brain region related to high-level brain functions such as recognition, learning and memory formation. In addition, abnormality of these functions observed in a brain of psychiatric patients. Thus, we studied a behavior analysis of the CAMDI knockout mice. As a result, the knockout mice showed a hypermobility, hypo-sociability and repetitive behavior. CAMDI gene located a 2q31.2 where is known as a candidate region for autism or related disease. These findings indicate that CAMDI have an important role for normal brain development and might be due to a psychiatric disorder.