2014 Fiscal Year Final Research Report
Suppression of experimental cerebral malaria by activation of nonlethal malaria parasite-specific CD4+T cells via MHC class II in mice coinfected with Plasmodium berghei ANKA and nonlethal Pb XAT
| Project/Area Number |
24790405
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Parasitology (including Sanitary zoology)
|
|---|
| Research Institution | Kyorin University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
KOBAYASHI Fumie 杏林大学, 医学部, 教授 (20118889)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | マラリア / 弱毒株 / 複合感染 / 病態重症化 / MHC class II / CD4+T細胞 / 比較ゲノム / 比較プロテオーム |
|---|
| Outline of Final Research Achievements |
Experimental cerebral malaria (ECM) caused by Plasmodium berghei (Pb) ANKA has been suppressed by coinfection with nonlethal Pb XAT. In this study, we showed that CD4+T cells which are activated via MHC class II play a crucial role for development of ECM in mice singly infected with Pb ANKA. The activation of CD4+T cells via MHC class II in Pb ANKA-infected mice was modulated by coinfection with Pb XAT, resulting in the suppression of ECM in mice coinfected with Pb ANKA and Pb XAT. Results from analysis using Ciita-deficient mice, which lack MHC class II expression, suggest that Pb XAT-specific CD4+T cells were induced via MHC class II in coinfected mice.
|
| Free Research Field |
医歯薬学
|
