2014 Fiscal Year Final Research Report
Construction of the inhibitor screening system which target the enzyme from Plasmodium falciparum.
| Project/Area Number |
24790406
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 結晶構造解析 / マラリア |
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| Outline of Final Research Achievements |
Aimed at creation of new anti-malarial drugs, I worked in the construction of inhibitor screening system for the enzyme from Plasmodium falciparum. Specifically, I focused on the non-mevalonate pathway, which is the essential metabolic pathway in the growth of Plasmodium falciparum. I aimed the construction of inhibitor screening system to target the 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) ,which is a particularly important enzyme in the pathway.
Although not lead to the construction of the screening system, I performed crystallization experiments in complex with novel inhibitors which collaborators provided me. I tried crystallization experiments complexed with several inhibitors and succeeded in obtaining crystals.Finally I was succeeded in the three-dimensional structural analysis.
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| Free Research Field |
構造生物学
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