2013 Fiscal Year Final Research Report
Functional analysis of a signal transduction system in pathogenic fungi Aspergillus fumigatus
| Project/Area Number |
24790410
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Chiba University |
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Principal Investigator |
HAGIWARA Daisuke 千葉大学, 真菌医学研究センター, 特任助教 (20612203)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 情報伝達系 / 二成分制御系 / ヒスチジンキナーゼ / MAPKカスケード / 浸透圧ストレス |
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| Research Abstract |
Recently, fungal infection has increased. In order to understand how the causative fungus Aspergillus fumigatus survives in a stressful environment and during infection, we focused on a stress response signaling mechanism, High Osmolar Glycerol (HOG) pathway. We constructed the gene deletion mutants of each component of the pathway, and investigated the components. We found that one histidine kinase, NikA, is involved in conidiation, hyphal morphogenesis, osmotic stress resistance, and fungicide response in A. fumigatus. These results will be useful for further understanding of the response mechanism against extracellular stresses and also for development of new drugs targeting this signaling pathway in A. fumigatus.
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