2013 Fiscal Year Final Research Report
Study of bacterial pathogenicity evolution by whole genome sequence comparison
| Project/Area Number |
24790412
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FURUTA Yoshikazu 東京大学, 新領域創成科学研究科, 特任助教 (40613667)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ゲノム比較解析 / ピロリ菌 / 次世代シークエンサー / ゲノム再編 / de novo assembly / Mate-pairライブラリ / ゲノム進化 |
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| Research Abstract |
We developed a method to sequence a whole genome sequence of Helicobacter pylori in high fidelity and high speed manner by utilizing next generation sequencing technology. We adopted this method to 30 strains of East Asian H. pylori strains and confirmed the following East Asian specific characters: (i) duplication of outer membrane protein coding gene oipA, (ii) inactivation of molybdenum related protein coding genes, (iii) 6 positions for genome inversion.
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