Xenophagy membrane dynamics

2013 Fiscal Year Final Research Report

• Project/Area Number: 24790413
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including Mycology)
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NOZAWA Takashi 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (10598858)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: オートファジー

Research Abstract

We could identify newly 4 Rab GTPases as an autophagy regulator during bacteial infection. These Rab proteins were not involved in starvation-induced autophagy, suggesting these regulators are responsible for autophagic membrane dynamics for bacteria.

Research Products

• [Journal Article] Development of two-step multiple PCR assay for typing of capsular polysaccharide synthesis gene clusters of Streptococcus suis (2014)
  • Author(s): M. Okura, C. Lachance, M. Osaki, T. Sekizaki, F. Maruyamam, T. Nozawa, Nakagawa, S. Hamada, C. Rossignol, M. Gottschalk, D. Takamatsu
  • Journal Title: J. Clin. Microbiol Volume: 52 Pages: 1714-9
  • Peer Reviewed
• [Journal Article] Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria (2013)
  • Author(s): Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, ... & Arimoto H
  • Journal Title: Mol Cell
  • Peer Reviewed
• [Journal Article] CRISPR regulation of intra-species diversification by limiting IS transposition and inter-cellular recombination (2013)
  • Author(s): T. Watanabe, T. Nozawa, C. Aikawa, A. Amano, F. Maruyama, and I. Nakagawa
  • Journal Title: Genome Biol. Evol Volume: 5 Pages: 1099-114
  • Peer Reviewed
• [Journal Article] Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis : Potential Mechanisms for the Generation of Capsular Variation (2013)
  • Author(s): M. Okura, D. Takamatsu, F. Maruyama, T. Nozawa, I. Nakagawa, M. Osaki, T. Sekizaki, M. Gottschalk, Y. Kumagai, and S. Hamada
  • Journal Title: Appl. Environ. Microbiol Volume: 79 Pages: 2796-2806
  • Peer Reviewed
• [Journal Article] The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection (2012)
  • Author(s): Nozawa T, Aikawa C, Goda A, Maruyama F, Hamada S, Nakagawa I
  • Journal Title: Cell Microbiol Volume: 14 Pages: 1149-65
  • Peer Reviewed
• [Presentation] Atg5-independent/Rab9a-dependent target of intracellular group A streptococcus (2014)
  • Author(s): 野澤孝志,野澤敦子,相川知宏,丸山史人,中川一路
  • Organizer: 第87回日本細菌学会総会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 20140326-28
• [Presentation] Contribution of recycling endosome in Group A Streptococcus induced autophagosome formation (2014)
  • Author(s): Bijaya Haobam,野澤孝志,野澤敦子,尾田誠一郎,相川知宏,丸山史人,中川一路
  • Organizer: 第87回日本細菌学会総会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 20140326-28
• [Presentation] The Small GTPase Rab30 regulates anti-bacterial autophagy (2014)
  • Author(s): 尾田誠一郎,野澤孝志,野澤敦子,相川知宏,丸山史人,中川一路
  • Organizer: 第87回日本細菌学会総会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 20140326-28
• [Presentation] Atg5-independent/Rab9A-dependent target of intracellular Group A Streptococcus (2013)
  • Author(s): Takashi Nozawa, Chihiro Aikawa, Shinichiro Oda, Akira Goda, Fumito Maruyama, and Ichiro Nakagawa
  • Organizer: FEMS 2013 (5th congress of european microbiologists)
  • Place of Presentation: ドイツ
  • Year and Date: 20130721-25
• [Presentation] A群レンサ球菌によるオートファジーを制御するRabタンパク質群 (2013)
  • Author(s): 野澤孝志、相川知宏、郷田瑛、丸山史人、中川一路
  • Organizer: 第86回日本細菌学会総会
  • Place of Presentation: 千葉県
  • Year and Date: 2013-03-18
• [Presentation] The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection (2012)
  • Author(s): Takashi Nozawa, Chihiro Aikawa, Akira Goda, Fumito Maruyama, Ichiro Nakagawa
  • Organizer: 第11回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 兵庫県
  • Year and Date: 2012-09-14
• [Presentation] バクテリオファージによる宿主細菌への獲得免疫の付与 (2012)
  • Author(s): 野澤孝志
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎県
  • Year and Date: 2012-03-28
• [Book] Rab Proteins in Autophagy: Streptococcus Model. Chapter contribution for the book "Autophagy, Infection and the Immune Response" (2014)
  • Author(s): Nozawa T and Nakagawa I
  • Publisher: Wiley-Blackwell
• [Remarks]
  • URL: http://www.tmd.ac.jp/grad/bac/index.html