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2013 Fiscal Year Final Research Report

Analysis of aminoglycoside-resistant genes in highly multidrug-resistant Pseudomonas aeruginosa

Research Project

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Project/Area Number 24790432
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bacteriology (including Mycology)
Research Institution独立行政法人国立国際医療研究センター

Principal Investigator

TADA Tatsuya  独立行政法人国立国際医療研究センター, その他部局等, その他 (00624644)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords多剤耐性緑膿菌 / 分子疫学 / 薬剤耐性因子 / アミノグリコシド / β-ラクタマーゼ
Research Abstract

We performed a molecular epidemiolygical study of 300 clinical isolates of Pseudomonas aeruginosa in 2011 in Japan. Of them, we found a novel aminoglycoside 6'-N-acetyltransferase gene, aac(6')-Iaj.The encoded protein, AAC(6')-Iaj, was found to consist of 184 amino acids, with 70% identity to AAC(6')-Ia. Escherichia coli transformed with a plasmid containing the aac(6')-Iaj gene acquired resistance to all aminoglycosides tested except gentamicin. Of note, aac(6')-Iaj contributed to the resistance to arbekacin.
In 2012, we found two novel IMP-type metallo-beta-lactamase variants, IMP-43 and IMP-44, which were identified in multidrug-resistant Pseudomonas aeruginosa isolates obtained in medical settings in Japan. These two variants had more efficient catalytic activities against all carbapenems tested, including dripenem, imipenem, meropenem and panipenem.

  • Research Products

    (12 results)

All 2014 2013 Other

All Journal Article (8 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Biochemical analysis of metallo-β-lactamase NDM-3 from a multidrug-resistant Escherichia coli strain isolated in Japan2014

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Kayo Shimada, Teruo Kirikae
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 58 Pages: 3538-3540

  • [Journal Article] Dissemination of 16S rRNA methylase ArmA-producing Acinetobacter baumannii and emergence of OXA-72 carbapenemase coproducers in Japan2014

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Kayo Shimada, Masahiro Shimojima, Teruo Kirikae
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 58 Pages: 2916-2920

  • [Journal Article] NDM-1 metalloβ-lactamase and ArmA 16S rRNA methylase producing Providencia rettgeri clinical isolates in Nepal2014

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Rajan K. Dahal, Manoj K. Sah, Hiroshi Ohara, Kayo Shimada, Teruo Kirikae, Bharat M. Pokhrel
    • Journal Title

      BMC Infect Dis

      Volume: 14 Pages: 56

  • [Journal Article] Dissemination of multidrug-resistant Klebsiella pneumoniae clinical isolates with various combinations of carbapenemases (NDM-1 and OXA-72) and 16S rRNA methylases (ArmA, RmtC and RmtF) in Nepal2013

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Rajan K. Dahal, Shyam K. Mishra, Hiroshi Ohara, Kayo Shimada, Teruo Kirikae, Bharat Pokhrel
    • Journal Title

      Int J Antimicrob Agents

      Volume: 42 Pages: 372-374

  • [Journal Article] IMP-43 and IMP-44 metallo-β-lactamases with increased carbapenemase acrivities in multidrug-resistant Pseudomonas aeruginosa2013

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Kayo Shimada, Masahiro Shimojima, Teruo Kirikae
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 57 Pages: 4427-4432

  • [Journal Article] Emergence of 16S rRNA methylase-producing Acinetobacter baumannii and Pseudomonas aeruginosa isolates in Vietnam2013

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Yasuyuki Kato, Norio Ohmagari, Nozomi Takeshita, Nguyen V. Hung, Doan M. Phuong, Truong A. Thu, Nguyen G. Binh, Nguyen Q. Anh, Tran T. T. Nga, Pham H. Truong, Phan T. Xuan, Le T. A. Thu, Nguyen T. Son, Teruo Kirikae
    • Journal Title

      BMC Infect Dis

      Volume: 13 Pages: 251

  • [Journal Article] NDM-8 metallo-β-lactamase in a multidrug-resistant Escherichia coli strain isolated in Nepal2013

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Rajan K. Dahal, Manoj K. Sah, Hiroshi Ohara, Teruo Kirikae, Bharat M. Pokhrel
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 57 Pages: 2394-2396

  • [Journal Article] Novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa2013

    • Author(s)
      Tatsuya Tada, Tohru Miyoshi-Akiyama, Kayo Shimada, Masahiro Shimojima, Teruo Kirikae
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 57 Pages: 96-100

  • [Presentation] 日本の医療施設で分離されたIMP-43およびIMP-44産生多剤耐性緑膿菌

    • Author(s)
      多田達哉、秋山徹、切替照雄
    • Organizer
      第87回日本細菌学会
  • [Presentation] 日本の医療施設で分離される多剤耐性アシネトバクターバウマニーの分子疫学解析

    • Author(s)
      切替照雄、多田達哉、秋山徹
    • Organizer
      第87回日本細菌学会
  • [Presentation] ネパールの医療施設で分離された院内感染起因菌としての多剤耐性グラム陰性菌の解析

    • Author(s)
      多田達哉、秋山徹、島田佳世、小原博、Pokhrel M. Bharat、切替照雄
    • Organizer
      第42回薬剤耐性菌研究会
  • [Remarks] 研究業績

    • URL

      http://www.rincgm.jp/individual/lab03/did_japanese/Publicationjp.html

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Published: 2015-06-25  

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