Elucidation of pathogenesis of hantavirus infection by using an animal model

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790433
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: Hokkaido University
• Principal Investigator: SHIMIZU Kenta 北海道大学, 医学(系)研究科(研究院), 助教 (20466840)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ハンタウイルス / 出血熱 / 病態 / 動物モデル / 糖蛋白質 / T細胞 / ケモカイン / 細胞性免疫

Outline of Final Research Achievements

Hantaviruses cause hemorrhagic fever with renal syndrome in humans. In this study, we tried to identify viral and host factors involved in pathogenesis by using a mouse model showing renal hemorrhage as in the case of patients. As a result, we found that amino acid at position 417 in viral glycoprotein Gn and host T cells are involved in the pathogenesis. In addition, we found that chemokines attracting cytotoxic T cells were significantly elevated at onset of disease, suggesting that excessive cell-mediated immunity induced by the chemokines have a role in the pathogenesis.

Free Research Field

ウイルス学