The study of attachment and entry mechanism of hepatitis E virus into hepatocyte

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790452
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: SHIOTA Tomoyuki 国立感染症研究所, その他部局等, 任期付研究員 (80616144)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: E型肝炎ウイルス(HEV) / HEV感受・非感受性細胞 / 網羅的遺伝子発現解析 / プロテオーム解析 / cDNAライブラリスクリーニング / レセプター候補 / 結合能 / 感染能

Outline of Final Research Achievements

Comparative analyses between hepatitis E virus (HEV) infection-permissive and -nonpermissive human hepatocytes by using gene expression profiling, proteome analysis and screening of cDNA library led to the identification of strong receptor candidate. We are now planning to elucidate the function of this candidate gene to viral attachment and entry into hepatocytes. To date, the effective method to control HEV infection is not yet established, but we believe this study will contribute to the development of effective vaccine and therapeutic drugs.

Free Research Field

ウイルス学